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AA is predominantly involved in different theories of aging mechanisms, and it is accepted that glucose-rich diets, shorter telomeres, cellular senescence, chronic inflammation, and ROS contribute to the aging process [13]
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In vitro studies have shown that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides